We are pleased to present a special issue of The Biophysicist on Teaching and Learning during COVID-19. The issue includes both Research Articles and shorter, informal Reports with papers on how formal learning and labs were taught remotely, as well as the even more difficult problem of how student research experiences were modified during this very challenging time. Other articles are related to the pedagogical aspects of the science behind COVID-19 that deal with aerosols and infection models. Finally, a Student Forum report describes the home-based experiments done by middle-school students who were learning remotely. We hope that this collection will be both enlightening and enjoyable to read, but that we do not have to organize such a special issue again!